Critical Structural and Functional Roles for the N-Terminal Insertion Sequence in Surfactant Protein B Analogs

BACKGROUND: Surfactant protein B (SP-B; 79 residues) belongs to the saposin protein superfamily, and plays functional roles in lung surfactant. The disulfide cross-linked, N- and C-terminal domains of SP-B have been theoretically predicted to fold as charged, amphipathic helices, suggesting their pa...

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Detalhes bibliográficos
Main Authors: Walther, Frans J., Waring, Alan J., Hernandez-Juviel, Jose M., Gordon, Larry M., Wang, Zhengdong, Jung, Chun-Ling, Ruchala, Piotr, Clark, Andrew P., Smith, Wesley M., Sharma, Shantanu, Notter, Robert H.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2805716/
https://ncbi.nlm.nih.gov/pubmed/20084172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0008672
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