Attenuated Listeria monocytogenes reprograms M2-polarized tumor-associated macrophages in ovarian cancer leading to iNOS-mediated tumor cell lysis

A principal mechanism by which tumors evade immune-mediated elimination is through immunosuppression. Previous approaches to tumor immunotherapy have focused on modifying the immunosuppressive environment with immune checkpoint inhibitors, cytokine therapy, and other modalities with the intent to ge...

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Hauptverfasser: Lizotte, Patrick H, Baird, Jason R, Stevens, Cynthia A, Lauer, Peter, Green, William R, Brockstedt, Dirk G, Fiering, Steven N
Format: Artigo
Sprache:Inglês
Veröffentlicht: Landes Bioscience 2014
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4106169/
https://ncbi.nlm.nih.gov/pubmed/25083323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.28926
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