Dual engagement of the NLRP3 and AIM2 inflammasomes by plasmodial-derived hemozoin and DNA during malaria

Hemozoin (Hz) is the crystalline detoxification product of hemoglobin in plasmodial-infected erythrocytes. We previously proposed that Hz can carry plasmodial DNA into a subcellular compartment accessible to Toll-like receptor 9 (TLR9), inducing an inflammatory signal. Hemozoin also activates the NL...

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Autori principali: Kalantari, Parisa, DeOliveira, Rosane B., Chan, Jennie, Corbett, Yolanda, Rathinam, Vijay, Stutz, Andrea, Latz, Eicke, Gazzinelli, Ricardo T., Golenbock, Douglas T., Fitzgerald, Katherine A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4105362/
https://ncbi.nlm.nih.gov/pubmed/24388751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.12.014
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