XBP1 Promotes Triple Negative Breast Cancer By Controlling the HIF1 α Pathway

Cancer cells induce a set of adaptive response pathways to survive in the face of stressors due to inadequate vascularization(1). One such adaptive pathway is the unfolded protein (UPR) or endoplasmic reticulum (ER) stress response mediated in part by the ER-localized transmembrane sensor IRE1(2) an...

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Main Authors: Chen, Xi, Iliopoulos, Dimitrios, Zhang, Qing, Tang, Qianzi, Greenblatt, Matthew B., Hatziapostolou, Maria, Lim, Elgene, Tam, Wai Leong, Ni, Min, Chen, Yiwen, Mai, Junhua, Shen, Haifa, Hu, Dorothy Z., Adoro, Stanley, Hu, Bella, Song, Minkyung, Tan, Chen, Landis, Melissa D., Ferrari, Mauro, Shin, Sandra J., Brown, Myles, Chang, Jenny C., Liu, X. Shirley, Glimcher, Laurie H.
Format: Artigo
Jezik:Inglês
Izdano: 2014
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4105133/
https://ncbi.nlm.nih.gov/pubmed/24670641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13119
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