CTSH regulates β-cell function and disease progression in newly diagnosed type 1 diabetes patients

Over 40 susceptibility loci have been identified for type 1 diabetes (T1D). Little is known about how these variants modify disease risk and progression. Here, we combined in vitro and in vivo experiments with clinical studies to determine how genetic variation of the candidate gene cathepsin H (CTS...

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Detalhes bibliográficos
Main Authors: Fløyel, Tina, Brorsson, Caroline, Nielsen, Lotte B., Miani, Michela, Bang-Berthelsen, Claus Heiner, Friedrichsen, Martin, Overgaard, Anne Julie, Berchtold, Lukas A., Wiberg, Anna, Poulsen, Pernille, Hansen, Lars, Rosinger, Silke, Boehm, Bernhard O., Ram, Ramesh, Nguyen, Quang, Mehta, Munish, Morahan, Grant, Concannon, Patrick, Bergholdt, Regine, Nielsen, Jens H., Reinheckel, Thomas, von Herrath, Matthias, Vaag, Allan, Eizirik, Decio Laks, Mortensen, Henrik B., Størling, Joachim, Pociot, Flemming
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4104872/
https://ncbi.nlm.nih.gov/pubmed/24982147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1402571111
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