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Direct Evaluation of tRNA Aminoacylation Status by the T-box Riboswitch Using Intermolecular Stacking and Steric Readout

T-boxes are gene-regulatory mRNA elements with which Gram-positive bacteria sense amino acid availability. T-boxes have two functional domains. Stem I recognizes the overall shape and anticodon of tRNA, while a 3′ domain evaluates its aminoacylation status, overcoming an otherwise stable transcripti...

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Main Authors: Zhang, Jinwei, Ferré-D’Amaré, Adrian R.
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4104367/
https://ncbi.nlm.nih.gov/pubmed/24954903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.05.017
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