Lactate Reduces Organ Injury in Toll-like Receptor- and Inflammasome-Mediated Inflammation via GPR81-mediated Suppression of Innate Immunity

BACKGROUND & AIMS: The NLRP3 inflammasome induces inflammation in response to organ injury, but little is known about its regulation. Toll-like receptors (TLRs) provide the first signal required for activation of the inflammasome and stimulate aerobic glycolysis to generate lactate. We examined...

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Bibliographic Details
Main Authors: Hoque, Rafaz, Farooq, Ahmad, Ghani, Ayaz, Gorelick, Fred, Mehal, Wajahat Zafar
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4104305/
https://ncbi.nlm.nih.gov/pubmed/24657625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2014.03.014
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