WIPI2 Links LC3 Conjugation with PI3P, Autophagosome Formation, and Pathogen Clearance by Recruiting Atg12–5-16L1

Mammalian cell homeostasis during starvation depends on initiation of autophagy by endoplasmic reticulum-localized phosphatidylinositol 3-phosphate (PtdIns(3)P) synthesis. Formation of double-membrane autophagosomes that engulf cytosolic components requires the LC3-conjugating Atg12–5-16L1 complex....

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Huvudupphovsmän: Dooley, Hannah C., Razi, Minoo, Polson, Hannah E.J., Girardin, Stephen E., Wilson, Michael I., Tooze, Sharon A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Cell Press 2014
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4104028/
https://ncbi.nlm.nih.gov/pubmed/24954904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.05.021
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