Computational Investigation of Locked Nucleic Acid (LNA) Nucleotides in the Active Sites of DNA Polymerases by Molecular Docking Simulations

Aptamers constitute a potential class of therapeutic molecules typically selected from a large pool of oligonucleotides against a specific target. With a scope of developing unique shorter aptamers with very high biostability and affinity, locked nucleic acid (LNA) nucleotides have been investigated...

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Bibliographic Details
Main Authors: Poongavanam, Vasanthanathan, Madala, Praveen K., Højland, Torben, Veedu, Rakesh N.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4103837/
https://ncbi.nlm.nih.gov/pubmed/25036012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0102126
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