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Dynamic and Multi-Pharmacophore Modeling for Designing Polo-Box Domain Inhibitors
The polo-like kinase 1 (Plk1) is a critical regulator of cell division that is overexpressed in many types of tumors. Thus, a strategy in the treatment of cancer has been to target the kinase activity (ATPase domain) or substrate-binding domain (Polo-box Domain, PBD) of Plk1. However, only few synth...
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| Huvudupphovsmän: | , , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Public Library of Science
2014
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4103762/ https://ncbi.nlm.nih.gov/pubmed/25036740 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0101405 |
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