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Covariate-modulated local false discovery rate for genome-wide association studies

Motivation: Genome-wide association studies (GWAS) have largely failed to identify most of the genetic basis of highly heritable diseases and complex traits. Recent work has suggested this could be because many genetic variants, each with individually small effects, compose their genetic architectur...

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Autors principals: Zablocki, Rong W., Schork, Andrew J., Levine, Richard A., Andreassen, Ole A., Dale, Anders M., Thompson, Wesley K.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4103587/
https://ncbi.nlm.nih.gov/pubmed/24711653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btu145
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