Mechanochemotransduction During Cardiomyocyte Contraction Is Mediated by Localized Nitric Oxide Signaling

Cardiomyocytes contract against a mechanical load during each heartbeat, and excessive mechanical stress leads to heart diseases. Using a cell-in-gel system that imposes an afterload during cardiomyocyte contraction, we found that nitric oxide synthase (NOS) was involved in transducing mechanical lo...

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Hauptverfasser: Jian, Zhong, Han, Huilan, Zhang, Tieqiao, Puglisi, Jose, Izu, Leighton T., Shaw, John A., Onofiok, Ekama, Erickson, Jeffery R., Chen, Yi-Je, Horvath, Balazs, Shimkunas, Rafael, Xiao, Wenwu, Li, Yuanpei, Pan, Tingrui, Chan, James, Banyasz, Tamas, Tardiff, Jil C., Chiamvimonvat, Nipavan, Bers, Donald M., Lam, Kit S., Chen-Izu, Ye
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4103414/
https://ncbi.nlm.nih.gov/pubmed/24643800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2005046
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