Histone deacetylase (HDAC) 1 and 2 are essential for accurate cell division and the pluripotency of embryonic stem cells

Histone deacetylases 1 and 2 (HDAC1/2) form the core catalytic components of corepressor complexes that modulate gene expression. In most cell types, deletion of both Hdac1 and Hdac2 is required to generate a discernible phenotype, suggesting their activity is largely redundant. We have therefore ge...

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Hauptverfasser: Jamaladdin, Shereen, Kelly, Richard D. W., O’Regan, Laura, Dovey, Oliver M., Hodson, Grace E., Millard, Christopher J., Portolano, Nicola, Fry, Andrew M., Schwabe, John W. R., Cowley, Shaun M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2014
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4103379/
https://ncbi.nlm.nih.gov/pubmed/24958871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1321330111
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