PER2 Controls Lipid Metabolism by Direct Regulation of PPARγ

Accumulating evidence highlights intriguing interplays between circadian and metabolic pathways. We show that PER2 directly and specifically represses PPARγ, a nuclear receptor critical in adipogenesis, insulin sensitivity and inflammatory response. PER2-deficient mice display altered lipid metaboli...

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Main Authors: Grimaldi, Benedetto, Bellet, Marina Maria, Katada, Sayako, Astarita, Giuseppe, Hirayama, Jun, Amin, Rajesh H., Granneman, James G., Piomelli, Daniele, Leff, Todd, Sassone-Corsi, Paolo
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4103168/
https://ncbi.nlm.nih.gov/pubmed/21035761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2010.10.005
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