Macrophage immunomodulation by breast cancer-derived exosomes requires Toll-like receptor 2-mediated activation of NF-κB

Growing evidence links tumor progression with chronic inflammatory processes and dysregulated activity of various immune cells. In this study, we demonstrate that various types of macrophages internalize microvesicles, called exosomes, secreted by breast cancer and non-cancerous cell lines. Although...

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Bibliografische gegevens
Hoofdauteurs: Chow, Amy, Zhou, Weiying, Liu, Liang, Fong, Miranda Y., Champer, Jackson, Van Haute, Desiree, Chin, Andrew R., Ren, Xiubao, Gugiu, Bogdan Gabriel, Meng, Zhipeng, Huang, Wendong, Ngo, Vu, Kortylewski, Marcin, Wang, Shizhen Emily
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2014
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4102923/
https://ncbi.nlm.nih.gov/pubmed/25034888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep05750
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