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Mechanisms of CFTR Functional Variants That Impair Regulated Bicarbonate Permeation and Increase Risk for Pancreatitis but Not for Cystic Fibrosis

CFTR is a dynamically regulated anion channel. Intracellular WNK1-SPAK activation causes CFTR to change permeability and conductance characteristics from a chloride-preferring to bicarbonate-preferring channel through unknown mechanisms. Two severe CFTR mutations (CFTR(sev)) cause complete loss of C...

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Bibliografische gegevens
Hoofdauteurs: LaRusch, Jessica, Jung, Jinsei, General, Ignacio J., Lewis, Michele D., Park, Hyun Woo, Brand, Randall E., Gelrud, Andres, Anderson, Michelle A., Banks, Peter A., Conwell, Darwin, Lawrence, Christopher, Romagnuolo, Joseph, Baillie, John, Alkaade, Samer, Cote, Gregory, Gardner, Timothy B., Amann, Stephen T., Slivka, Adam, Sandhu, Bimaljit, Aloe, Amy, Kienholz, Michelle L., Yadav, Dhiraj, Barmada, M. Michael, Bahar, Ivet, Lee, Min Goo, Whitcomb, David C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2014
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4102440/
https://ncbi.nlm.nih.gov/pubmed/25033378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004376
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