Mechanisms of CFTR Functional Variants That Impair Regulated Bicarbonate Permeation and Increase Risk for Pancreatitis but Not for Cystic Fibrosis

CFTR is a dynamically regulated anion channel. Intracellular WNK1-SPAK activation causes CFTR to change permeability and conductance characteristics from a chloride-preferring to bicarbonate-preferring channel through unknown mechanisms. Two severe CFTR mutations (CFTR(sev)) cause complete loss of C...

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主要な著者: LaRusch, Jessica, Jung, Jinsei, General, Ignacio J., Lewis, Michele D., Park, Hyun Woo, Brand, Randall E., Gelrud, Andres, Anderson, Michelle A., Banks, Peter A., Conwell, Darwin, Lawrence, Christopher, Romagnuolo, Joseph, Baillie, John, Alkaade, Samer, Cote, Gregory, Gardner, Timothy B., Amann, Stephen T., Slivka, Adam, Sandhu, Bimaljit, Aloe, Amy, Kienholz, Michelle L., Yadav, Dhiraj, Barmada, M. Michael, Bahar, Ivet, Lee, Min Goo, Whitcomb, David C.
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2014
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4102440/
https://ncbi.nlm.nih.gov/pubmed/25033378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004376
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