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A hydrophobic barrier deep within the inner pore of the TWIK-1 K2P potassium channel

Recent X-ray crystal structures of the two-pore domain (K2P) family of potassium channels have revealed a unique structural architecture at the point where the cytoplasmic bundle-crossing gate is found in most other tetrameric K(+) channels. However, despite the apparently open nature of the inner p...

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Autors principals: Aryal, Prafulla, Abd-Wahab, Firdaus, Bucci, Giovanna, Sansom, Mark S. P., Tucker, Stephen J.
Format: Artigo
Idioma:Inglês
Publicat: Nature Pub. Group 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4102122/
https://ncbi.nlm.nih.gov/pubmed/25001086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms5377
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