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Sirtuin 1 inhibition delays cyst formation in autosomal-dominant polycystic kidney disease
Autosomal-dominant polycystic kidney disease (ADPKD) is caused by mutations in either PKD1 or PKD2 and is characterized by the development of multiple bilateral renal cysts that replace normal kidney tissue. Here, we used Pkd1 mutant mouse models to demonstrate that the nicotinamide adenine dinucleo...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Clinical Investigation
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4101988/ https://ncbi.nlm.nih.gov/pubmed/23778143 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI64401 |
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