A randomized phase II presurgical trial of transdermal 4-Hydroxytamoxifen gel versus oral tamoxifen in women with ductal carcinoma in situ of the breast

PURPOSE: Local transdermal therapy to the breast may achieve effective target-organ drug delivery, while diminishing systemic effects. We conducted a randomized, double-blind, placebo-controlled phase II trial comparing transdermal 4-hydroxytamoxifen gel (4-OHT) to oral tamoxifen (oral-T) in women w...

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Main Authors: Lee, Oukseub, Page, Katherine, Ivancic, David, Helenowski, Irene, Parimi, Vamsi, Sullivan, Megan, Margenthaler, Julie A., Chatterton, Robert T., Jovanovic, Borko, Dunn, Barbara K., Heckman-Stoddard, Brandy M., Foster, Kathleen, Muzzio, Miguel, Shklovskaya, Julia, Skripkauskas, Silvia, Kulesza, Piotr, Green, David, Hansen, Nora M., Bethke, Kevin P., Jeruss, Jacqueline S., Bergan, Raymond, Khan, Seema A.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4101910/
https://ncbi.nlm.nih.gov/pubmed/25028506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-3045
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