In vitro human skin permeation of endoxifen: potential for local transdermal therapy for primary prevention and carcinoma in situ of the breast

PURPOSE: Oral tamoxifen, a triphenylethylene (TPE), is useful for breast cancer prevention, but its adverse effects limit acceptance by women. Tamoxifen efficacy is related to its major metabolites 4-hydroxytamoxifen (4-OHT) and N-desmethyl-4-hydroxytamoxifen (endoxifen [ENX]). Transdermal delivery...

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Hlavní autoři: Lee, Oukseub, Ivancic, David, Chatterton, Robert T, Rademaker, Alfred W, Khan, Seema A
Médium: Artigo
Jazyk:Inglês
Vydáno: Dove Medical Press 2011
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3846656/
https://ncbi.nlm.nih.gov/pubmed/24367176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/BCTT.S20821
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