Antiviral activity of human oligoadenylate synthetases-like (OASL) is mediated by enhancing retinoic acid-inducible gene I (RIG-I) signaling

Virus infection is sensed in the cytoplasm by retinoic acid-inducible gene I (RIG-I, also known as DDX58), which requires RNA and polyubiquitin binding to induce type I interferon (IFN), and activate cellular innate immunity. We show that the human IFN-inducible oligoadenylate synthetases-like (OASL...

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Autors principals: Zhu, Jianzhong, Zhang, Yugen, Ghosh, Arundhati, Cuevas, Rolando A., Forero, Adriana, Dhar, Jayeeta, Ibsen, Mikkel Søes, Schmid-Burgk, Jonathan Leo, Schmidt, Tobias, Ganapathiraju, Madhavi K., Fujita, Takashi, Hartmann, Rune, Barik, Sailen, Hornung, Veit, Coyne, Carolyn B., Sarkar, Saumendra N.
Format: Artigo
Idioma:Inglês
Publicat: 2014
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4101812/
https://ncbi.nlm.nih.gov/pubmed/24931123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2014.05.007
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