Loss of lamin B1 results in prolongation of S phase and decondensation of chromosome territories

Nuclear lamin B1 (LMNB1) constitutes one of the major structural proteins in the lamina mesh. We silenced the expression of LMNB1 by RNA interference in the colon cancer cell line DLD-1 and showed a dramatic redistribution of H3K27me3 from the periphery to a more homogeneous nuclear dispersion. In a...

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Autors principals: Camps, Jordi, Wangsa, Darawalee, Falke, Martin, Brown, Markus, Case, Chanelle M., Erdos, Michael R., Ried, Thomas
Format: Artigo
Idioma:Inglês
Publicat: Federation of American Societies for Experimental Biology 2014
Matèries:
Research Communications
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4101663/
https://ncbi.nlm.nih.gov/pubmed/24732130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.14-250456
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