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Impairments of hepatic gluconeogenesis and ketogenesis in PPARα-deficient neonatal mice

Peroxisome proliferator activated receptor-α (PPARα) is a master transcriptional regulator of hepatic metabolism and mediates the adaptive response to fasting. Here, we demonstrate the roles for PPARα in hepatic metabolic adaptations to birth. Like fasting, nutrient supply is abruptly altered at bir...

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Bibliografiske detaljer
Main Authors: Cotter, David G., Ercal, Baris, André d'Avignon, D., Dietzen, Dennis J., Crawford, Peter A.
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4101633/
https://ncbi.nlm.nih.gov/pubmed/24865983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00087.2014
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