Focal adhesion kinase: An alternative focus for anti-angiogenesis therapy in ovarian cancer

This investigation describes the clinical significance of phosphorylated focal adhesion kinase (FAK) at the major activating tyrosine site (Y397) in epithelial ovarian cancer (EOC) cells and tumor-associated endothelial cells. FAK gene amplification as a mechanism for FAK overexpression and the effe...

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Bibliographische Detailangaben
Hauptverfasser: Stone, Rebecca L, Baggerly, Keith A, Armaiz-Pena, Guillermo N, Kang, Yu, Sanguino, Angela M, Thanapprapasr, Duangmani, Dalton, Heather J, Bottsford-Miller, Justin, Zand, Behrouz, Akbani, Rehan, Diao, Lixia, Nick, Alpa M, DeGeest, Koen, Lopez-Berestein, Gabriel, Coleman, Robert L, Lutgendorf, Susan, Sood, Anil K
Format: Artigo
Sprache:Inglês
Veröffentlicht: Landes Bioscience 2014
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4100993/
https://ncbi.nlm.nih.gov/pubmed/24755674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.28882
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