Modelling of a genetically diverse evolution of Systemic Mastocytosis with Chronic Myelomonocytic Leukemia (SM-CMML) by Next Generation Sequencing

BACKGROUND: Systemic mastocytosis (SM) is a heterogenous, clonal mast cell (MC) proliferation, rarely associated with clonal hematologic non-mast cell lineage disease (SM-AHNMD). KIT(D816V) is regarded as driver-mutation in SM-AHNMD. METHODS: DNA isolated from peripheral blood (PB) of an SM-CMML pat...

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Autors principals: Rechsteiner, Markus, Müller, Rouven, Reineke, Tanja, Goede, Jeroen, Bohnert, Annette, Zhong, Qing, Manz, Markus G, Moch, Holger, Wild, Peter J, Zimmermann, Dieter R, Tinguely, Marianne
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2014
Matèries:
Rapid Communication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4100747/
https://ncbi.nlm.nih.gov/pubmed/25032071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2162-3619-3-18
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