A zanamivir dimer with prophylactic and enhanced therapeutic activity against influenza viruses

OBJECTIVES: Emerging drug resistance to antiviral therapies is an increasing challenge for the treatment of influenza virus infections. One new antiviral compound, BTA938, a dimeric derivative of the viral neuraminidase inhibitor zanamivir, contains a 14-carbon linker bridging two zanamivir moieties...

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Detalhes bibliográficos
Main Authors: Tarbet, E. Bart, Hamilton, Stephanie, Vollmer, Almut H., Luttick, Angela, Ng, Wy Ching, Pryor, Melinda, Hurst, Brett L., Crawford, Simon, Smee, Donald F., Tucker, Simon P.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4100710/
https://ncbi.nlm.nih.gov/pubmed/24777908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dku127
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