Secondary metabolism pathway polymorphisms and plasma efavirenz concentrations in HIV-infected adults with CYP2B6 slow metabolizer genotypes

OBJECTIVES: Efavirenz is widely prescribed for HIV-1 infection, and CYP2B6 polymorphisms 516G→T and 983T→C define efavirenz slow metabolizer genotypes. To identify genetic predictors of higher plasma efavirenz concentrations beyond these two common functional alleles, we characterized associations w...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Haas, David W., Kwara, Awewura, Richardson, Danielle M., Baker, Paxton, Papageorgiou, Ioannis, Acosta, Edward P., Morse, Gene D., Court, Michael H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2014
Soggetti:
Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4100708/
https://ncbi.nlm.nih.gov/pubmed/24729586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dku110
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi