Secondary metabolism pathway polymorphisms and plasma efavirenz concentrations in HIV-infected adults with CYP2B6 slow metabolizer genotypes

OBJECTIVES: Efavirenz is widely prescribed for HIV-1 infection, and CYP2B6 polymorphisms 516G→T and 983T→C define efavirenz slow metabolizer genotypes. To identify genetic predictors of higher plasma efavirenz concentrations beyond these two common functional alleles, we characterized associations w...

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Hlavní autoři: Haas, David W., Kwara, Awewura, Richardson, Danielle M., Baker, Paxton, Papageorgiou, Ioannis, Acosta, Edward P., Morse, Gene D., Court, Michael H.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2014
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4100708/
https://ncbi.nlm.nih.gov/pubmed/24729586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dku110
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