Acquired Dependence Of Acute Myeloid Leukemia On The DEAD-BOX RNA Helicase DDX5

Acute myeloid leukemia (AML) therapy involves compounds that are cytotoxic to both normal and cancer cells and relapsed AML is resistant to subsequent chemotherapy. Thus agents are needed that selectively kill AML cells with minimal toxicity. Here we report that AML is dependent on DDX5 and that inh...

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Main Authors: Mazurek, Anthony, Park, Youngkyu, Miething, Cornelius, Wilkinson, John E., Gillis, Jesse, Lowe, Scott W., Vakoc, Christopher R., Stillman, Bruce
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4100070/
https://ncbi.nlm.nih.gov/pubmed/24910429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.05.019
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