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Enhanced solubility and intestinal absorption of candesartan cilexetil solid dispersions using everted rat intestinal sacs
OBJECTIVE: Candesartan cilexetil (CAN) is a poor aqueous soluble compound and a P-glycoprotein (P-gp) efflux pump substrate. These key factors are responsible for its incomplete intestinal absorption. METHODS: In this study, we investigated to enhance the absorption of CAN by improving its solubilit...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4099560/ https://ncbi.nlm.nih.gov/pubmed/25067902 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsps.2013.03.006 |
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