Inactivation of the cardiomyocyte glucagon-like peptide-1 receptor (GLP-1R) unmasks cardiomyocyte-independent GLP-1R-mediated cardioprotection()()

GLP-1R agonists improve outcomes in ischemic heart disease. Here we studied GLP-1R-dependent adaptive and cardioprotective responses to ventricular injury. Glp1r(−/−) hearts exhibited chamber-specific differences in gene expression, but normal mortality and left ventricular (LV) remodeling after myo...

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Autors principals: Ussher, John R., Baggio, Laurie L., Campbell, Jonathan E., Mulvihill, Erin E., Kim, Minsuk, Kabir, M. Golam, Cao, Xiemin, Baranek, Benjamin M., Stoffers, Doris A., Seeley, Randy J., Drucker, Daniel J.
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2014
Matèries:
Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4099509/
https://ncbi.nlm.nih.gov/pubmed/25061556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2014.04.009
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