Inactivation of the cardiomyocyte glucagon-like peptide-1 receptor (GLP-1R) unmasks cardiomyocyte-independent GLP-1R-mediated cardioprotection()()

GLP-1R agonists improve outcomes in ischemic heart disease. Here we studied GLP-1R-dependent adaptive and cardioprotective responses to ventricular injury. Glp1r(−/−) hearts exhibited chamber-specific differences in gene expression, but normal mortality and left ventricular (LV) remodeling after myo...

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Detalhes bibliográficos
Main Authors: Ussher, John R., Baggio, Laurie L., Campbell, Jonathan E., Mulvihill, Erin E., Kim, Minsuk, Kabir, M. Golam, Cao, Xiemin, Baranek, Benjamin M., Stoffers, Doris A., Seeley, Randy J., Drucker, Daniel J.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2014
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4099509/
https://ncbi.nlm.nih.gov/pubmed/25061556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2014.04.009
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