Transgenic Expression of Human Glial Cell Line-Derived Neurotrophic Factor from Integration-Deficient Lentiviral Vectors is Neuroprotective in a Rodent Model of Parkinson's Disease

Standard integration-proficient lentiviral vectors (IPLVs) are effective at much lower doses than other vector systems and have shown promise for gene therapy of Parkinson's disease (PD). Their main drawback is the risk of insertional mutagenesis. The novel biosafety-enhanced integration-defici...

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Main Authors: Lu-Nguyen, Ngoc B., Broadstock, Martin, Schliesser, Maximilian G., Bartholomae, Cynthia C., von Kalle, Christof, Schmidt, Manfred, Yáñez-Muñoz, Rafael J.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2014
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4098822/
https://ncbi.nlm.nih.gov/pubmed/24635742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2014.003
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