VEGF antagonism reduces edema formation and tissue damage after ischemia/reperfusion injury in the mouse brain

VEGF is mitogenic, angiogenic, and a potent mediator of vascular permeability. VEGF causes extravasation of plasma protein in skin bioassays and increases hydraulic conductivity in isolated perfused microvessels. Reduced tissue oxygen tension triggers VEGF expression, and increased protein and mRNA...

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Main Authors: van Bruggen, Nicholas, Thibodeaux, Harold, Palmer, James T., Lee, Wyne P., Fu, Ling, Cairns, Belinda, Tumas, Daniel, Gerlai, Robert, Williams, Simon-Peter, Campagne, Menno van Lookeren, Ferrara, Napoleone
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 1999
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC409867/
https://ncbi.nlm.nih.gov/pubmed/10587525
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