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A PDZ-interacting domain in CFTR is an apical membrane polarization signal

Polarization of the cystic fibrosis transmembrane conductance regulator (CFTR), a cAMP-activated chloride channel, to the apical plasma membrane of epithelial cells is critical for vectorial transport of chloride in a variety of epithelia, including the airway, pancreas, intestine, and kidney. Howev...

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Published in:J Clin Invest
Main Authors: Moyer, Bryan D., Denton, Jerod, Karlson, Katherine H., Reynolds, Donna, Wang, Shusheng, Mickle, John E., Milewski, Michal, Cutting, Garry R., Guggino, William B., Li, Min, Stanton, Bruce A.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 1999
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Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC409842/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10562297/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI7453
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