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Airway epithelial CFTR mRNA expression in cystic fibrosis patients after repetitive administration of a recombinant adenovirus

We sought to evaluate the ability of an E1(–), E3(–) adenovirus (Ad) vector (Ad(GV)CFTR.10) to transfer the normal human cystic fibrosis transmembrane conductance regulator (CFTR) cDNA to the airway epithelium of individuals with cystic fibrosis (CF). We administered Ad(GV)CFTR.10 at doses of 3 × 10...

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Publicado no:J Clin Invest
Principais autores: Harvey, Ben-Gary, Leopold, Philip L., Hackett, Neil R., Grasso, Tina M., Williams, P. Mickey, Tucker, Ayly L., Kaner, Robert J., Ferris, Barbara, Gonda, Igor, Sweeney, Theresa D., Ramalingam, Ramachandran, Kovesdi, Imre, Shak, Steven, Crystal, Ronald G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 1999
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Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC409826/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10545523/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI7935
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