Airway epithelial CFTR mRNA expression in cystic fibrosis patients after repetitive administration of a recombinant adenovirus

We sought to evaluate the ability of an E1(–), E3(–) adenovirus (Ad) vector (Ad(GV)CFTR.10) to transfer the normal human cystic fibrosis transmembrane conductance regulator (CFTR) cDNA to the airway epithelium of individuals with cystic fibrosis (CF). We administered Ad(GV)CFTR.10 at doses of 3 × 10...

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Pubblicato in:	J Clin Invest
Autori principali:	Harvey, Ben-Gary, Leopold, Philip L., Hackett, Neil R., Grasso, Tina M., Williams, P. Mickey, Tucker, Ayly L., Kaner, Robert J., Ferris, Barbara, Gonda, Igor, Sweeney, Theresa D., Ramalingam, Ramachandran, Kovesdi, Imre, Shak, Steven, Crystal, Ronald G.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1999
Soggetti:	Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC409826/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10545523/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI7935
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