The cis-regulatory effect of an Alzheimer's disease-associated poly-T locus on expression of TOMM40 and APOE genes

INTRODUCTION: We investigated the TOMM40-APOE genomic region that has been associated with the risk and age of onset of late-onset Alzheimer's disease (LOAD) to determine if a highly polymorphic, intronic polyT within this region (rs10524523, hereafter 523) affects expression of the APOE and TO...

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Main Authors: Linnertz, Colton, Anderson, Lauren, Gottschalk, William, Crenshaw, Donna, Lutz, Michael W., Allen, Jawara, Saith, Sunita, Mihovilovic, Mirta, Burke, James R., Welsh-Bohmer, Kathleen A., Roses, Allen D., Chiba-Falek, Ornit
Format: Artigo
Language:Inglês
Published: 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4098029/
https://ncbi.nlm.nih.gov/pubmed/24439168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jalz.2013.08.280
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