Activation of SOX2 expression by BRD4-NUT oncogenic fusion drives neoplastic transformation in NUT midline carcinoma

BRD4 is implicated in the pathogenesis of a number of different cancers. It is also the target of translocation t(15;19) that accounts for the highly aggressive NUT midline carcinoma (NMC). We discovered that t(15;19) NMC cells display the ability to grow into stem cell-like spheres and express an e...

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主要な著者: Wang, Ranran, Liu, Wei, Helfer, Christine M., Bradner, James E., Hornick, Jason L., Janicki, Susan M., French, Christopher A., You, Jianxin
フォーマット: Artigo
言語:Inglês
出版事項: 2014
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Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4097982/
https://ncbi.nlm.nih.gov/pubmed/24736545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-13-2658
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