Recombinant Covalently Closed Circular Hepatitis B Virus DNA Induces Prolonged Viral Persistence in Immunocompetent Mice

It remains crucial to develop a laboratory model for studying hepatitis B virus (HBV) chronic infection. We hereby produced a recombinant covalently closed circular DNA (rcccDNA) in view of the key role of cccDNA in HBV persistence. A loxP-chimeric intron was engineered into a monomeric HBV genome i...

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Autors principals: Qi, Zhihua, Li, Gaiyun, Hu, Hao, Yang, Chunhui, Zhang, Xiaoming, Leng, Qibin, Xie, Youhua, Yu, Demin, Zhang, Xinxin, Gao, Yueqiu, Lan, Ke, Deng, Qiang
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2014
Matèries:
Pathogenesis and Immunity
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4097776/
https://ncbi.nlm.nih.gov/pubmed/24807718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01024-14
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