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Phosphorylation of Herpes Simplex Virus 1 dUTPase Upregulated Viral dUTPase Activity To Compensate for Low Cellular dUTPase Activity for Efficient Viral Replication

We recently reported that herpes simplex virus 1 (HSV-1) protein kinase Us3 phosphorylated viral dUTPase (vdUTPase) at serine 187 (Ser-187) to upregulate its enzymatic activity, which promoted HSV-1 replication in human neuroblastoma SK-N-SH cells but not in human carcinoma HEp-2 cells. In the prese...

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Bibliografiske detaljer
Main Authors: Kato, Akihisa, Hirohata, Yoshitaka, Arii, Jun, Kawaguchi, Yasushi
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4097765/
https://ncbi.nlm.nih.gov/pubmed/24760895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00603-14
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