Hepatocyte-specific IKKβ expression aggravates atherosclerosis development in APOE*3-Leiden mice

OBJECTIVE: The liver is the key organ involved in systemic inflammation, but the relation between hepatic inflammation and atherogenesis is poorly understood. Since nuclear factor-κB (NF-κB) is a central regulator of inflammatory processes, we hypothesized that chronically enhanced hepatic NF-κB act...

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Autors principals: Wong, Man C., van Diepen, Janna A., Hu, Lihui, Guigas, Bruno, de Boer, Hetty C., van Puijvelde, Gijs H., Kuiper, Johan, van Zonneveld, Anton J., Shoelson, Steven E., Voshol, Peter J., Romijn, Johannes A., Havekes, Louis M., Tamsma, Jouke T., Rensen, Patrick C.N., Hiemstra, Pieter S., Berbée, Jimmy F.P.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4097174/
https://ncbi.nlm.nih.gov/pubmed/21798539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.atherosclerosis.2011.06.055
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