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Inhibition of the ubiquitin-proteasome pathway does not protect against ventilator-induced accelerated proteolysis or atrophy in the diaphragm

BACKGROUND: Mechanical ventilation (MV) is a life-saving intervention in patients with acute respiratory failure. However, prolonged MV results in ventilator-induced diaphragm dysfunction (VIDD), a condition characterized by both diaphragm fiber atrophy and contractile dysfunction. Previous work has...

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Main Authors: Smuder, Ashley J., Nelson, W. Bradley, Hudson, Matthew B., Kavazis, Andreas N., Powers, Scott K.
格式: Artigo
語言:Inglês
出版: 2014
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4096949/
https://ncbi.nlm.nih.gov/pubmed/24681580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0000000000000245
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