Motor Function Deficits Following Chronic Prenatal Ethanol Exposure are Linked to Impairments in Insulin/IGF, Notch and Wnt Signaling in the Cerebellum

BACKGROUND: Fetal alcohol spectrum disorder (FASD) is associated with deficits in cerebellar function that can persist through adolescence. Previous studies demonstrated striking inhibition of insulin and insulin-like growth factor (IGF) signaling in ethanol-exposed cerebella. OBJECTIVES: We sought...

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Hauptverfasser: Tong, Ming, Ziplow, Jason, Chen, William Cy, Nguyen, Quynh-Giao, Kim, Charles, de la Monte, Suzanne M
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4096945/
https://ncbi.nlm.nih.gov/pubmed/25035811
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