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Cigarette smoke disrupts the integrity of airway adherens junctions through the aberrant interaction of p120-catenin with the cytoplasmic tail of MUC1

Adherens junctions (AJs) containing epithelial cadherin (E-cad) bound to p120-catenin (p120ctn) and β-catenin (β-ctn) play a crucial role in regulating cell–cell adhesion. Cigarette smoke abrogates cell–cell adhesion between epithelial cells by disrupting E-cad, a hallmark of epithelial–mesenchymal...

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Hlavní autoři: Zhang, Lili, Gallup, Marianne, Zlock, Lorna, Basbaum, Carol, Finkbeiner, Walter E., McNamara, Nancy A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4096852/
https://ncbi.nlm.nih.gov/pubmed/22833523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/path.4070
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