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Design, synthesis and evaluation of estradiol-linked genotoxicants as anticancer agents
A series of bifunctional compounds was prepared consisting of 17β estradiol linked to a DNA damaging N,N-bis(2-chloroethyl)-aniline. The objective of our studies was to detem1ine the characteristics of the linker that permitted both reaction with DNA and binding of the resultant covalent adducts to...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4096836/ https://ncbi.nlm.nih.gov/pubmed/15203171 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2004.04.064 |
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