Ciliopathy-associated gene Cc2d2a promotes assembly of subdistal appendages on the mother centriole during cilia biogenesis

The primary cilium originates from the mother centriole and participates in critical functions during organogenesis. Defects in cilia biogenesis or function lead to pleiotropic phenotypes. Mutations in centrosome-cilia gene CC2D2A result in Meckel and Joubert syndromes. Here we generate a Cc2d2a(-/-...

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Main Authors: Veleri, Shobi, Manjunath, Souparnika H., Fariss, Robert N., May-Simera, Helen, Brooks, Matthew, Foskett, Trevor A., Gao, Chun, Longo, Teresa A., Liu, Pinghu, Nagashima, Kunio, Rachel, Rivka A., Li, Tiansen, Dong, Lijin, Swaroop, Anand
Format: Artigo
Language:Inglês
Published: 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4096663/
https://ncbi.nlm.nih.gov/pubmed/24947469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms5207
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