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Late Dual Endothelin Receptor Blockade with Bosentan Restores Impaired Cerebrovascular Function in Diabetes
AIMS: Up-regulation of the endothelin (ET) system in type-2 diabetes increases contraction and decreases relaxation in basilar artery. We showed that 1) ET-receptor antagonism prevents diabetes-mediated cerebrovascular dysfunction; and 2) glycemic control prevents activation of the ET-system in diab...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4096617/ https://ncbi.nlm.nih.gov/pubmed/24434796 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.lfs.2013.12.231 |
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