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Dual Endothelin Receptor Antagonism with Bosentan Reverses Established Vascular Remodeling and Dysfunctional Angiogenesis in Diabetic Rats: Relevance to Glycemic Control

AIMS: We have shown that diabetes causes cerebrovascular remodeling in part by the activation of the endothelin (ET-1) system in a glucose-dependent manner. We also reported increased yet dysfuctional cerebral angiogenesis in diabetes. Here, we tested the hypothesis that dual ET-1 receptor antagonis...

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Autors principals: Abdelsaid, Mohammed, Kaczmarek, Jessica, Coucha, Maha, Ergul, Adviye
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4103965/
https://ncbi.nlm.nih.gov/pubmed/24447630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.lfs.2014.01.008
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