Dysfunctional survival-signaling and stress-intolerance in aged murine and human myocardium

Changes in cytoprotective signaling may influence cardiac aging, and underpin sensitization to ischemic insult and desensitization to ‘anti-ischemic’ therapies. We tested whether age-dependent shifts in ischemia-reperfusion (I-R) tolerance in murine and human myocardium are associated with reduced e...

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Main Authors: Peart, Jason N., Pepe, Salvatore, Reichelt, Melissa E., Beckett, Nikkie, Hoe, Louise See, Ozberk, Victoria, Niesman, Ingrid R., Patel, Hemal H., Headrick, John P.
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4096533/
https://ncbi.nlm.nih.gov/pubmed/24316036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exger.2013.11.015
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